| Rang | Joueurs | Buts | Matchs | Buts/Matchs | |
|---|
| 1 | Samuel Eto'o (FC Barcelone) | 15 | 16 | 0.94 | |
| 2 | David Villa (Valence CF) | 13 | 17 | 0.76 | |
| 3 | Diego Forlan (Atletico Madrid) | 11 | 12 | 0.92 | |
| - | Gonzalo Higuain (Real Madrid) | 11 | 14 | 0.79 | |
| 5 | Lionel Messi (FC Barcelone) | 10 | 14 | 0.71 | |
| 6 | Sergio Agüero (Atletico Madrid) | 9 | 16 | 0.56 | |
| - | Thierry Henry (FC Barcelone) | 9 | 14 | 0.64 | |
| 8 | Alvaro Sánchez Negredo (Almeria) | 8 | 16 | 0.50 | |
| 9 | Nabil Baha (Malaga) | 7 | 17 | 0.41 | |
| - | Mate Bilic (Sporting Gijon) | 7 | 16 | 0.44 | |
| 11 | Fernando Llorente (Athletic Bilbao) | 6 | 17 | 0.35 | |
| - | Maximiliano Maxi Rodriguez (Atletico Madrid) | 6 | 15 | 0.40 | |
| - | Achille Emana (Betis Séville) | 6 | 16 | 0.38 | |
| - | Jose Javier Barkero Saludes (Numancia) | 6 | 16 | 0.38 | |
| - | Mohamed Tchité (Racing Santander) | 6 | 15 | 0.40 | |
| - | Gonzalez Blanco Raul (Real Madrid) | 6 | 16 | 0.38 | |
| - | Juan Manuel Mata (Valence CF) | 6 | 17 | 0.35 | |
| - | Joseba Llorente (Villarreal) | 6 | 13 | 0.46 | |
| - | Giuseppe Rossi (Villarreal) | 6 | 12 | 0.50 | |
| 20 | Andoni Iraola (Athletic Bilbao) | 5 | 16 | 0.31 | |
| - | Angel Lafita (Deportivo La Corogne) | 5 | 15 | 0.33 | |
| - | Frédéric Kanouté (FC Séville) | 5 | 14 | 0.36 | |
| - | Juan Albin (Getafe) | 5 | 15 | 0.33 | |
| - | Aritz Aduriz (Real Majorque) | 5 | 16 | 0.31 | |
| - | Adrian Colunga (Recreativo Huelva) | 5 | 17 | 0.29 | |
| 26 | Simão (Atletico Madrid) | 4 | 15 | 0.27 | |
| - | Florent Sinama-Pongolle (Atletico Madrid) | 4 | 12 | 0.33 | |
| - | Renato (FC Séville) | 4 | 11 | 0.36 | |
| - | Francisco Javier Casquero (Getafe) | 4 | 15 | 0.27 | |
| - | Manu del Moral (Getafe) | 4 | 14 | 0.29 | |
| - | Sergio Barbosa Valente Duda (Malaga) | 4 | 16 | 0.25 | |
| - | Dos Santos Eliseu Pereira (Malaga) | 4 | 16 | 0.25 | |
| - | Javad Nekounam (Osasuna) | 4 | 17 | 0.24 | |
| - | Ruud Van Nistelrooy (Real Madrid) | 4 | 6 | 0.67 | |
| - | Rafael Van der Vaart (Real Madrid) | 4 | 16 | 0.25 | |
| - | Henok Goitom (Real Valladolid) | 4 | 11 | 0.36 | |
| - | Jonathan Sesma (Real Valladolid) | 4 | 17 | 0.24 | |
| - | Carmelo (Sporting Gijon) | 4 | 11 | 0.36 | |
| - | Diego Castro (Sporting Gijon) | 4 | 15 | 0.27 | |
| - | Vicente (Valence CF) | 4 | 12 | 0.33 | |
| - | Santiago Cazorla (Villarreal) | 4 | 17 | 0.24 | |
| 42 | Pablo Daniel Piatti (Almeria) | 3 | 14 | 0.21 | |
| - | Sergio Garcia (Betis Séville) | 3 | 14 | 0.21 | |
| - | Mehmet Aurelio (Betis Séville) | 3 | 15 | 0.20 | |
| - | Luis Garcia (Espanyol Barcelone) | 3 | 16 | 0.19 | |
| - | Raul Tamudo (Espanyol Barcelone) | 3 | 12 | 0.25 | |
| - | Eidur Gudjohnsen (FC Barcelone) | 3 | 10 | 0.30 | |
| - | Seydou Keita (FC Barcelone) | 3 | 14 | 0.21 | |
| - | Xavi Hernandez (FC Barcelone) | 3 | 16 | 0.19 | |
| - | Correia Adriano (FC Séville) | 3 | 13 | 0.23 | |
| - | Ernesto Javier Chevanton (FC Séville) | 3 | 4 | 0.75 | |
| - | Luis Fabiano (FC Séville) | 3 | 12 | 0.25 | |
| - | Roberto Soldado (Getafe) | 3 | 15 | 0.20 | |
| - | Ikechukwu Uche (Getafe) | 3 | 13 | 0.23 | |
| - | Antonio Apono (Malaga) | 3 | 14 | 0.21 | |
| - | Gorka Gallego Brit (Numancia) | 3 | 13 | 0.23 | |
| - | Javier Del Pino (Numancia) | 3 | 15 | 0.20 | |
| - | Asier Goiria (Numancia) | 3 | 15 | 0.20 | |
| - | Walter Pandiani (Osasuna) | 3 | 6 | 0.50 | |
| - | Achille Webo (Real Majorque) | 3 | 16 | 0.19 | |
| - | Nestor Fabian Canobbio (Real Valladolid) | 3 | 12 | 0.25 | |
| - | Pedro Pedro Leon (Real Valladolid) | 3 | 13 | 0.23 | |
| - | Angel Manuel Vivar Dorado (Real Valladolid) | 3 | 15 | 0.20 | |
| - | David Barral (Sporting Gijon) | 3 | 16 | 0.19 | |
| - | Sanchez Joaquin (Valence CF) | 3 | 16 | 0.19 | |
| 66 | David David Lopez (Athletic Bilbao) | 2 | 16 | 0.13 | |
| - | Lizardi Joseba Etxeberria (Athletic Bilbao) | 2 | 11 | 0.18 | |
| - | Javier Javi Martinez (Athletic Bilbao) | 2 | 15 | 0.13 | |
| - | Johnny Heitinga (Atletico Madrid) | 2 | 13 | 0.15 | |
| - | Abella Damia (Betis Séville) | 2 | 15 | 0.13 | |
| - | Luciano Monzon (Betis Séville) | 2 | 6 | 0.33 | |
| - | Hugo Pavone (Betis Séville) | 2 | 13 | 0.15 | |
| - | Rodolfo Bodipo (Deportivo La Corogne) | 2 | 8 | 0.25 | |
| - | Luis Karminski Filipe (Deportivo La Corogne) | 2 | 17 | 0.12 | |
| - | Andrés Guardado (Deportivo La Corogne) | 2 | 15 | 0.13 | |
| - | Alberto Lopo (Deportivo La Corogne) | 2 | 16 | 0.13 | |
| - | Gonzalez Sergio (Deportivo La Corogne) | 2 | 12 | 0.17 | |
| - | Joan Verdu (Deportivo La Corogne) | 2 | 15 | 0.13 | |
| - | Ferran Corominas Telechea (Espanyol Barcelone) | 2 | 15 | 0.13 | |
| - | Moises Hurtado (Espanyol Barcelone) | 2 | 16 | 0.13 | |
| - | Sergio Sanchez (Espanyol Barcelone) | 2 | 15 | 0.13 | |
| - | Daniel Alves (FC Barcelone) | 2 | 16 | 0.13 | |
| - | Andres Iniesta (FC Barcelone) | 2 | 10 | 0.20 | |
| - | Gonzalez Jesus Navas (FC Séville) | 2 | 16 | 0.13 | |
| - | Enzo Maresca (FC Séville) | 2 | 13 | 0.15 | |
| - | Jaime Gavilan (Getafe) | 2 | 14 | 0.14 | |
| - | Lopez Alvarez Adrian (Malaga) | 2 | 15 | 0.13 | |
| - | Manuel Lolo (Malaga) | 2 | 8 | 0.25 | |
| - | Juan Carlos Moreno (Numancia) | 2 | 11 | 0.18 | |
| - | Eduardo Fernandes Pereira Gome Dady (Osasuna) | 2 | 7 | 0.29 | |
| - | Ivan Marcano (Racing Santander) | 2 | 16 | 0.13 | |
| - | Jonathan Pereira Rodriguez (Racing Santander) | 2 | 15 | 0.13 | |
| - | Juan Valera (Racing Santander) | 2 | 11 | 0.18 | |
| - | Arjen Robben (Real Madrid) | 2 | 11 | 0.18 | |
| - | Wesley Sneijder (Real Madrid) | 2 | 10 | 0.20 | |
| - | Juan Fernando Arango (Real Majorque) | 2 | 17 | 0.12 | |
| - | José Manuel Jurado (Real Majorque) | 2 | 15 | 0.13 | |
| - | Fernando Varela (Real Majorque) | 2 | 16 | 0.13 | |
| - | Javier Camunas (Recreativo Huelva) | 2 | 16 | 0.13 | |
| - | Javier Javi Fuego (Recreativo Huelva) | 2 | 16 | 0.13 | |
| - | Francisco Javi Guerrero (Recreativo Huelva) | 2 | 14 | 0.14 | |
| - | Marco Rubén (Recreativo Huelva) | 2 | 15 | 0.13 | |
| - | Francisco Maldonado (Sporting Gijon) | 2 | 9 | 0.22 | |
| - | Luis Moran (Sporting Gijon) | 2 | 14 | 0.14 | |
| - | Manuel Henriques Fernandes (Valence CF) | 2 | 17 | 0.12 | |
| - | David Silva (Valence CF) | 2 | 4 | 0.50 | |
| - | Robert Pires (Villarreal) | 2 | 14 | 0.14 | |
| - | Gonzalo Rodriguez (Villarreal) | 2 | 10 | 0.20 | |
| - | Marcos Senna (Villarreal) | 2 | 16 | 0.13 | |
| 110 | Santiago Acasiete (Almeria) | 1 | 4 | 0.25 | |
| - | José Manuel Flores Chico (Almeria) | 1 | 9 | 0.11 | |
| - | Miguel Angel Corona (Almeria) | 1 | 15 | 0.07 | |
| - | Juan Manuel Ortiz (Almeria) | 1 | 13 | 0.08 | |
| - | Hernán Darío Pellerano (Almeria) | 1 | 14 | 0.07 | |
| - | Esteban Solari (Almeria) | 1 | 4 | 0.25 | |
| - | Joseba Garmendia (Athletic Bilbao) | 1 | 7 | 0.14 | |
| - | Inigo Velez (Athletic Bilbao) | 1 | 3 | 0.33 | |
| - | Ion Velez (Athletic Bilbao) | 1 | 12 | 0.08 | |
| - | Francisco Yeste (Athletic Bilbao) | 1 | 13 | 0.08 | |
| - | Maniche (Atletico Madrid) | 1 | 14 | 0.07 | |
| - | Garcia Raul Garcia (Atletico Madrid) | 1 | 17 | 0.06 | |
| - | José Mari (Betis Séville) | 1 | 8 | 0.13 | |
| - | Juanito (Betis Séville) | 1 | 16 | 0.06 | |
| - | Juan Manuel Juanma (Betis Séville) | 1 | 12 | 0.08 | |
| - | Omar Bravo (Deportivo La Corogne) | 1 | 8 | 0.13 | |
| - | José Eduardo Castro (Deportivo La Corogne) | 1 | 13 | 0.08 | |
| - | Miguel Angel Ferrer Mista (Deportivo La Corogne) | 1 | 11 | 0.09 | |
| - | Iván Riki (Deportivo La Corogne) | 1 | 13 | 0.08 | |
| - | Daniel Jarque (Espanyol Barcelone) | 1 | 16 | 0.06 | |
| - | Roman Fernando Martinez (Espanyol Barcelone) | 1 | 13 | 0.08 | |
| - | Valdo (Espanyol Barcelone) | 1 | 9 | 0.11 | |
| - | Rafael Marquez (FC Barcelone) | 1 | 13 | 0.08 | |
| - | Yaya Gnégnéri Touré (FC Barcelone) | 1 | 13 | 0.08 | |
| - | Tom De Mul (FC Séville) | 1 | 3 | 0.33 | |
| - | Ndri Romaric (FC Séville) | 1 | 17 | 0.06 | |
| - | Daniel Alberto Cata Diaz (Getafe) | 1 | 15 | 0.07 | |
| - | Cosmin Contra (Getafe) | 1 | 11 | 0.09 | |
| - | Esteban Granero (Getafe) | 1 | 15 | 0.07 | |
| - | Miguel Helder Rosario (Malaga) | 1 | 11 | 0.09 | |
| - | Alberto Luque (Malaga) | 1 | 12 | 0.08 | |
| - | Carlos Aranda (Numancia) | 1 | 2 | 0.50 | |
| - | Carlos Bellvis Llorens (Numancia) | 1 | 15 | 0.07 | |
| - | Cisma Domingo (Numancia) | 1 | 16 | 0.06 | |
| - | Mario Martinez (Numancia) | 1 | 14 | 0.07 | |
| - | Domingo Nagore (Numancia) | 1 | 17 | 0.06 | |
| - | Marin Santiago Ezquerro (Osasuna) | 1 | 9 | 0.11 | |
| - | Hector Hector Font (Osasuna) | 1 | 12 | 0.08 | |
| - | Juan Francisco Torres Juanfran (Osasuna) | 1 | 14 | 0.07 | |
| - | Miguel Miguel Flano (Osasuna) | 1 | 15 | 0.07 | |
| - | Jaroslav Plasil (Osasuna) | 1 | 12 | 0.08 | |
| - | Javier Garcia Portillo (Osasuna) | 1 | 12 | 0.08 | |
| - | Krisztian Vadocz (Osasuna) | 1 | 7 | 0.14 | |
| - | Gonzalo Ruiz Colsa (Racing Santander) | 1 | 15 | 0.07 | |
| - | Ezequiel Garay (Racing Santander) | 1 | 12 | 0.08 | |
| - | Juanjo (Racing Santander) | 1 | 13 | 0.08 | |
| - | Pedro Munitis (Racing Santander) | 1 | 13 | 0.08 | |
| - | Rodríguez Oscar Serrano (Racing Santander) | 1 | 16 | 0.06 | |
| - | Nikola Zigic (Racing Santander) | 1 | 1 | 1.00 | |
| - | Rubén De la Red (Real Madrid) | 1 | 7 | 0.14 | |
| - | Fernando Gago (Real Madrid) | 1 | 11 | 0.09 | |
| - | Jose Maria Guti (Real Madrid) | 1 | 12 | 0.08 | |
| - | Gabriel Heinze (Real Madrid) | 1 | 9 | 0.11 | |
| - | Javier Pedro Saviola (Real Madrid) | 1 | 7 | 0.14 | |
| - | Cleber Santana (Real Majorque) | 1 | 13 | 0.08 | |
| - | José Miguel Josemi (Real Majorque) | 1 | 15 | 0.07 | |
| - | Alhassane Keita (Real Majorque) | 1 | 10 | 0.10 | |
| - | David Navarro (Real Majorque) | 1 | 13 | 0.08 | |
| - | Rubio Alvaro Robles (Real Valladolid) | 1 | 15 | 0.07 | |
| - | Javier Baraja (Real Valladolid) | 1 | 11 | 0.09 | |
| - | Jose Antonio Garcia Calvo (Real Valladolid) | 1 | 10 | 0.10 | |
| - | Pedro Lopez Munoz (Real Valladolid) | 1 | 16 | 0.06 | |
| - | Haris Medunjanin (Real Valladolid) | 1 | 11 | 0.09 | |
| - | Bartholomew Ogbeche (Real Valladolid) | 1 | 8 | 0.13 | |
| - | Manuel Fernandez Victor (Real Valladolid) | 1 | 13 | 0.08 | |
| - | Aitor Fernandez (Recreativo Huelva) | 1 | 12 | 0.08 | |
| - | Roberto Canella (Sporting Gijon) | 1 | 16 | 0.06 | |
| - | Kike Mateo (Sporting Gijon) | 1 | 11 | 0.09 | |
| - | Raul Albiol (Valence CF) | 1 | 16 | 0.06 | |
| - | Ruano Alexis (Valence CF) | 1 | 11 | 0.09 | |
| - | Ruben Baraja (Valence CF) | 1 | 12 | 0.08 | |
| - | Josmer Altidore (Villarreal) | 1 | 6 | 0.17 | |
| - | Ruben Cani (Villarreal) | 1 | 6 | 0.17 | |
| - | Joan Capdevila (Villarreal) | 1 | 16 | 0.06 | |
| - | Sebastian Eguren (Villarreal) | 1 | 13 | 0.08 | |
| - | Ariel Ibagaza (Villarreal) | 1 | 14 | 0.07 | |
